Canagliflozin (Invokana®): a First-in-Class Anti-diabetic Drug
نویسندگان
چکیده
منابع مشابه
Canagliflozin (invokana), a novel oral agent for type-2 diabetes.
656 P&T® • November 2013 • Vol. 38 No. 1
متن کاملSevere Ketoacidosis Associated with Canagliflozin (Invokana): A Safety Concern.
Canagliflozin (Invokana) is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor that was first introduced in 2013 for the treatment of type 2 diabetes mellitus (DM). Though not FDA approved yet, its use in type 1 DM has been justified by the fact that its mechanism of action is independent of insulin secretion or action. However, some serious side effects, including severe anion gap m...
متن کاملCanagliflozin-Induced Diabetic Ketoacidosis
INTRODUCTION Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are relatively new antihyperglycemic agents that lower renal glucose reabsorption. They are used as adjunctive therapy to standard diabetes treatment. CASE REPORT We present the case of a 62-year-old woman with a past medical history of type 2 diabetes mellitus and sudden-onset diabetic ketoacidosis (DKA). Use of canagliflozin, ...
متن کاملAcute pancreatitis in the use of canagliflozin: A rare side-effect of the novel therapy for type 2 diabetes mellitus
Canagliflozin (Invokana) is an innovative treatment for type 2 diabetes mellitus (DM) approved in a new class acknowledged as sodium-glucose co-transporter 2 inhibitors. Acute pancreatitis is a very rare side effect with an incidence <1%. a 50-year-old white male with DM type 2 presented to the emergency department with acute onset of abdominal pain after 4 days treatment with canagliflozin. He...
متن کاملTransdermal Patch of Anti-Diabetic Drug
In the present work, monolithic matrix transdermal systems containing Drug x were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 32 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected as d...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2013
ISSN: 2250-1177
DOI: 10.22270/jddt.v3i3.490